How long can Zepbound stay out of the fridge?
Zepbound (tirzepatide)
Keep it in the fridge. If needed, each pen or vial can be kept unrefrigerated, up to 86°F, for up to 21 days.
- Best
- Fridge (36°F to 46°F)
- Out of the fridge
- Up to 21 days, not above 86°F
Good to know
- Keep it in the original carton to protect it from light.
- Do not freeze, and do not use it if it froze.
Source: the FDA label on DailyMed, last checked October 14, 2026. Labels change, so check the product in hand. Questions about a patient's medicine go to the pharmacist.
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